I love this. I made three, one for my hubby for Valentine's Day, one for my sister-in-law for her birthday, and one for my friend for Christmas! I used Bighugelabs.com to make the mosaic, and this Flickr group for the photos (Totally awesome!) I wanted mine to be in black and white; that's an easy fix using pretty much any photo software. I use Digital Image Pro 9. Now all I have to do is find some square thrift store frames, paint them white or black, and voila :) Yesterday I actually did find a small silver square frame (opening is 5x5) while out thrifting, still new in the box and bubble wrap, for only 90c. Score!
Of course, I can't take credit for this idea. I saw it on pinterest, of course! Here are the ones I found on pinterest for your viewing pleasure: